• Rothe Kanchan. R
• Dabhade M. P

The crystal-co-agglomerate technique has been performed as promising valued particle design technique for enhancing SLty and DisL rate, compressibility and micrometric properties. “Crystallo-co-agglomeration is an extension of spherical crystallization technique,which enables simultaneous crystallization and agglomeration of two or more drugs or crystallization of a drug and its simultaneous agglomeration with another drug or excipient.” The selected drug was characterized and identified by melting point SLty, partion coefficient, IR, DSC, XRD. and for analysis of drug uv spectroscopy is done . For crystal-co-agglomerates polymers and solvent system are selected and used with different concentration. Crystal-co-agglomerates are obtained with help of polymer, bridging liquid good solvent, bad solvent etc. Initial batches of crystal-co-agglomerates were obtained of different concentration of Peg6000 and pvpk30. SLty data was obtained in triplicate of preliminary batches. Optimization is done by applying 3² factorial design 9 batches where obtained and further evaluated SLty of it. Out of 9 optimized batches F9 batch was further used for study depending on SLty data. Crystal-co-agglomerate showed enhancement in physicochemical and micrometric properties. From the above optimized crystal-co-agglomerate batch Fast dissolving tablets were formulated by using various concentration of super-disintegrants by direct compression method and different batches were studied for DisL study and disintegration time. From above discussion it was concluded that Fast dissolving tablet were prepared by direct compression method exhibited disintegration time 42 sec and improved DisLrate

Polyethylene glycol/effects. Flurbiprofen/solubility. Flurbiprofen/dissolution rate. Drugcarrier compatibility/study. Dissolution efficiency.

"SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE FLURBIPROFEN BY CRYALLO-CO-AGGLOMERATION APPROACH", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 11, page no.783-805, November-2020, Available :http://www.jetir.org/papers/JETIR2011245.pdf

"SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE FLURBIPROFEN BY CRYALLO-CO-AGGLOMERATION APPROACH", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 11, page no. pp783-805, November-2020, Available at : http://www.jetir.org/papers/JETIR2011245.pdf