• Kale Nitin S.
• Gaikwad Sachin
• Dr. Gambhire M.S

Objective: The intension behind the formulation of theses dosage form is due to and sustained release of drug for effective treatements. The attempt is going to developed gastroretentive floating systems by using suitable polymer. In the present research work we are using the polymer such as HPMC for maintaining the sustained release action and enhancing the floating behaviours. In the study we have formulated nine batches for formulating the concentration of polymer and other excipients with acceptable sustained release action. Method: The optimized batch are formulated by using the excipients as drug,gas generating agent as sodium bicarbonate, polymer as HPMC which showing the sustained action, have enhancing the floating behaviours and these batch show the 12 hours sustained release action about 99% release of drug. Result: The prepared tablet are evaluated by pre-compressional and post-compressional parameter. From all of formulated batchs the F6 batch show the optimized results in these formulation polymer ratio is 1:1 ratio they resulted as 99% drug release action, having the floating lag time 18 second and floated upto 12 hours. Conclusion: From above experimental results the gastro retentive drug delivery system of dexketoprofen trometamol tablet are successfully prepared and shows several advantages.

Dexketoprofen Trometamol, Floating drug delivery system,HPMC.

"Formulation and Evaluation of Gastro Retentive Drug Delivery System of Dexketoprofen Trometamol", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 11, page no.1050-1077, November-2020, Available :http://www.jetir.org/papers/JETIR2011281.pdf

"Formulation and Evaluation of Gastro Retentive Drug Delivery System of Dexketoprofen Trometamol", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 11, page no. pp1050-1077, November-2020, Available at : http://www.jetir.org/papers/JETIR2011281.pdf