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Published in:

Volume 7 Issue 11
November-2020
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2011312


Registration ID:
303717

Page Number

76-101

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Title

Formulation, Development and Evaluation of Cefexime Trihydrate Periodantalfilms For Management of Periodontitis

Abstract

Local therapy has three potential advantages: decreased drug doses, increased drug concentration at the site of infection, and reduced systemic side effects such as gastrointestinal distress. Treatment of periodontitis with a localized drug delivery system aims at delivering therapeutic agents at a sufficient level inside the periodontal pocket and at the same time minimizes the side effects associated with systemic drug administration. Hence, drug delivery systems containing antibacterial agents are used for delivery to the periodontal pocket. For the present study, cefixime trihydrate(CFT) is selected as a model drug. CFT is third-generation cephalosporin antibacterial agent which acts on third & last cell wall synthesis To prepare and evaluate dental film containing cefixime trihydrate for the treatment of periodontitis to achieve more concentration of drug at the site, thereby reducing drug toxicity and drug resistance developed by organisms. The drug was incorporated into Chitosan and fabricated as a film in three altered concentrations 10, 20, and 30% w/w to the weight of the polymer. The films containing the drug content (10, 20, & 30% w/w) were further cross-linked with glutaraldehyde 2%, which was aimed to extend and control the drug release for more number of days. The in-vitro release studies showed an initial burst release of the drug by more than 40% and the release was sustained up to seven days and 12 days for the non-cross-linked and cross- linked films, respectively. Through the % release study, the films persisted intact, without any disintegration.

Key Words

cefixime trihydrate, Periodantalfilms Periodontal diseases

Cite This Article

"Formulation, Development and Evaluation of Cefexime Trihydrate Periodantalfilms For Management of Periodontitis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 11, page no.76-101, November-2020, Available :http://www.jetir.org/papers/JETIR2011312.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"Formulation, Development and Evaluation of Cefexime Trihydrate Periodantalfilms For Management of Periodontitis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 11, page no. pp76-101, November-2020, Available at : http://www.jetir.org/papers/JETIR2011312.pdf

Publication Details

Published Paper ID: JETIR2011312
Registration ID: 303717
Published In: Volume 7 | Issue 11 | Year November-2020
DOI (Digital Object Identifier):
Page No: 76-101
Country: yeola , Maharashtra , India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication


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