• D.M. Agase
• S.B. Zade
• M.S.Markam
• T.S.Kothe
• A.S.Soni,A. S. Kale,P. M. Mohurle

The present study has been undertaken to investigate the prognostic role of plasma Glutathione-s-transferases (GSTs) as a biomarker for leukemia. GSTs comprise a family of water-soluble enzymes involved in the detoxification of foreign compounds. The increase in GSTs is a major contributing factor to drug resistance. The present study revealed that the mean GST activity in the plasma of leukemia patients was significantly higher as compared to the control group. There was no significant difference (p<0.05) between plasma GST activity of different classes of leukemia. There was a significant increase (p<0.01) in plasma GST activity of leukemia patients in each class of leukemia after chemotherapy. The patients who achieved complete remission demonstrated significantly low plasma GST activity, but patients who achieved partial remission and the non-responsive patients demonstrated significantly high plasma GST activity.

Keywords: Biomarkers, chemotherapy, GSTs, Leukemia, Prognostic

"GLUTATHIONE S-TRANSFERASES AS A PROGNOSTIC BIOMARKER FOR LEUKEMIA", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 12, page no.1434-1439, December-2020, Available :http://www.jetir.org/papers/JETIR2012188.pdf

"GLUTATHIONE S-TRANSFERASES AS A PROGNOSTIC BIOMARKER FOR LEUKEMIA", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 12, page no. pp1434-1439, December-2020, Available at : http://www.jetir.org/papers/JETIR2012188.pdf