• Kiranpreet Kaur
• Sazal Patyar

Traumatic brain injury (TBI) refers to a blunt, penetrating, or acceleration/deceleration force-derived craniocerebral injury. It may occur due to accidents, falls, injury or blow to head. It causes manifestations at cellular, molecular and organ level changing the lifestyle. It results in memory deficits, neurological or neuropsychological abnormalities and even death. It is considered as a major cause of deaths and disabilities. Due to its heterogeneous and complex nature, it is very challenging to explore pathogenesis of TBI and develop effective therapeutic measures for the management this neurotrauma. Various animal models for induction of TBI like fluid percussion model, weight drop method and blast induced injuries have been designed to study the diverse aspects of this neurotrauma. Most of these models have been quite successful in mimicking the conditions of human injury. However, keeping in view the ethical challenges, development of clinically relevant models need to be encouraged.

Traumatic brain injury, neurotrauma, animal models, fluid percussion injury, controlled cortical impact.

"Pre-clinical models for Traumatic Brain Injury: A Short Review ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 12, page no.1492-1500, December-2020, Available :http://www.jetir.org/papers/JETIR2012195.pdf

"Pre-clinical models for Traumatic Brain Injury: A Short Review ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 12, page no. pp1492-1500, December-2020, Available at : http://www.jetir.org/papers/JETIR2012195.pdf