• Sulaiman Muhammad Sani

Diabetic nephropathy is the main complication in diabetic patients. It leads to renal failure and end stage renal disease (ESRD) worldwide. Increment of kidneys size, glomerulosis, and increase level of albumin in urine, glomerular hypertrophy and thickening of glomerular basement membrane Diabetic nephropathy are the main characteristic of Diabetic nephropathy (DN). Persistent high glucose level in the blood results in hemodynamic changes and mechanical changes in the glomerular which is responsible for gene expression changes as well as alteration downstream transcription factors. Oxidative stress can be defined as over production of reactive oxygen species. Different drugs such as simvastatin Andrographolide Schisandrin B, Diosmin, Lycium chinense and Lycium chinense have anti-oxidant property, Most of these drugs increase the production off exogenous antioxidant which include reduced glutathione (GSH) and catalase (CAT).

Oxidative stress, antioxidant, cytokines, inflammation, apoptosis, fibrosis, reactive oxygen species

"Diabetic nephropathy: A short review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 12, page no.113-122, December-2020, Available :http://www.jetir.org/papers/JETIR2012215.pdf

"Diabetic nephropathy: A short review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 12, page no. pp113-122, December-2020, Available at : http://www.jetir.org/papers/JETIR2012215.pdf