UGC Approved Journal no 63975(19)

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Published in:

Volume 7 Issue 12
December-2020
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2012232


Registration ID:
303620

Page Number

240-257

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Title

FORMULATION AND EVALUATION OF ORODISPERSIBLE LIQUISOLID COMPACTS OF KETOCONAZOLE USING CO-PROCESSED SUPERDISINTEGRANTS

Abstract

Objective: Drug dissolution is a rate limiting step for the bioavailability of many BCS Class II drugs. The bioavailability of such drugs can be improved by the application of various solubility enhancement techniques. Liquisolid technique is a novel technique. It is used to improve the dissolution rate of the poorly water soluble drugs like Ketoconazole. The aim of the present study was to enhance the dissolution of a practically insoluble Ketoconazole by liquisolid compact technique and to enhance the onset of action by Orodispersible tablet technique. Materials and methods: Orodispersible liquisolid compact of Ketoconazole were prepared by using PEG 400, Microcrystalline cellulose PH 102 and Aerosil 200 as non-volatile solvent, carrier, coating material respectively and co-processed superdisintegrants (Crosspovidone and croscarmellose sodium) in the ratio of 1:1, 1:2, 1:3. Results: Orodispersible liquisolid compacts of Ketoconazole tablets (F6) containing co-processed superdisintegrants in the ratio of 1:3 exhibits quick disintegration time and maximum drug release Conclusion: This research work may be useful to formulate Orodispersible tablets using Liquisolid technique which may give rapid onset of action by rapid absorption, maximize efficacy and hence increase patient compliance.

Key Words

Orodispersible Liquisolid compacts, poorly soluble drugs, co-processed super-disintegrants, dissolution rate, bioavailability

Cite This Article

"FORMULATION AND EVALUATION OF ORODISPERSIBLE LIQUISOLID COMPACTS OF KETOCONAZOLE USING CO-PROCESSED SUPERDISINTEGRANTS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 12, page no.240-257, December-2020, Available :http://www.jetir.org/papers/JETIR2012232.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"FORMULATION AND EVALUATION OF ORODISPERSIBLE LIQUISOLID COMPACTS OF KETOCONAZOLE USING CO-PROCESSED SUPERDISINTEGRANTS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 12, page no. pp240-257, December-2020, Available at : http://www.jetir.org/papers/JETIR2012232.pdf

Publication Details

Published Paper ID: JETIR2012232
Registration ID: 303620
Published In: Volume 7 | Issue 12 | Year December-2020
DOI (Digital Object Identifier):
Page No: 240-257
Country: Dehradun, Uttarakhand, India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication


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