• Parul Sharma
• Kritigya Mishra
• Dr. Pawan Kumar Gupta
• Rahul Vij
• Shubham Bisht

Tyrosinase plays an important role in melanin synthesis by directly regulating the amount of melanin produced unlike other enzymes, which can only modify the synthesized melanin in the biochemical pathway. Tyrosinase is basically involved in the pigmentation of skin, eyes and hair in mammals which provides protection against UV rays. Tyrosinase is an oxygen oxidoreductase enzyme which acts with other compounds as donor and incorporates an oxygen atom for depicting its principal characteristic. This enzyme is also used for the therapeutic purposes namely L-DOPA drug, which is used to treat Parkinson’s disease, manufacturing of lincomycin antibiotic and treating various neurological diseases. This enzyme has also been used in the food bioprocessing, agricultural and environmental industries. Inhibition of tyrosinase pose various strategies to develop new depigmenting agents which consequently has great applications in medical and cosmetic products. Natural and synthetic tyrosinase inhibitors has been reported. The tyrosinase inhibitors forms an important class of clinical antimelanoma drugs out of which very few comes out as effective and safe.

Tyrosinase, Melanogenesis, Tyrosinase inhibitors, Melanin, Dopaquinone

"Different Natural and Synthetic Tyrosinase Inhibitors and their Application", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 1, page no.179-190, January-2021, Available :http://www.jetir.org/papers/JETIR2101227.pdf

"Different Natural and Synthetic Tyrosinase Inhibitors and their Application", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 1, page no. pp179-190, January-2021, Available at : http://www.jetir.org/papers/JETIR2101227.pdf