• simran
• mr.keshav jindal
• karishma mahajan
• Kritika Thakur

The solubility of drugs is an important factor for pharmaceutical formulation. The solubility of the drug more important for the success of the drug should reach the site of action. The bioavail-ability and the solubility of the drug, are also important for the pharmacological effect of any formulation, especially in the case of oral dosage form .so many times to formulate poorly water-soluble drugs becomes very challenging. Absorption and dissolution rates may decrease by the poor solubility of the drug, so the solubility of the drug is important to improve by methods like salt formulation, solid dispersion, co-solvency, the addition of solubilizing agent, to enhance the dissolution rate of the drug all these approaches are mostly used, sometimes the desired bioavail-ability enhancement of the drug by these techniques may not be achieved always. In this review, we will study the several techniques which are used to increase the solubility of poorly soluble drugs by reducing particle size, adjustment of pH, solid dispersion and hydrotropy, etc

Keywords: Solubility Enhancement, bioavailability, hydrotrophy, solid dispersion.

"solubility enhancement techniques.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 2, page no.2138-2146, February-2021, Available :http://www.jetir.org/papers/JETIR2102260.pdf

"solubility enhancement techniques.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 2, page no. pp2138-2146, February-2021, Available at : http://www.jetir.org/papers/JETIR2102260.pdf