• Anusha Murali
• Shinu krishnan

Infection and antimicrobial resistance are persistent and correlated problems in Intensive care units (ICUs). They are directly or indirectly associated with increased morbidity and mortality. The common sites of infection in ICU - acquired infections are the respiratory tract, urinary tract, bloodstream, skin and soft tissue, gastrointestinal tract, and cardiovascular system. The treatment with beta-lactam antibiotics has led to a global spread of drug resistance especially with extended-spectrum Beta-lactamases (ESBLs) which render penicillins, narrow and broad-spectrum cephalosporins, and monobactams ineffective for treatment. Carbapenem resistance has been reported with increasing frequency worldwide in the last two decades. Production of the enzymes, carbapenemases by gram-negative bacilli has been one of the important mechanisms for resistance to carbapenems along with others such as the development of efflux pumps, and mutational alterations in the expression and/or function of porins. Hence the current study was carried out to detect and characterize carbapenemases in gram-negative bacterial infections in critical care units by using phenotypic and genotypic methods.

carbapenem. resistance ,gram negative bacilli

"Acquisition of Carbapenem- resistant of gram negative bacilli in critical care units; Molecular Epidemiology", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 4, page no.303-317, April-2021, Available :http://www.jetir.org/papers/JETIR2104139.pdf

"Acquisition of Carbapenem- resistant of gram negative bacilli in critical care units; Molecular Epidemiology", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 4, page no. pp303-317, April-2021, Available at : http://www.jetir.org/papers/JETIR2104139.pdf