• Disagar Tejal Kumari Manojbhai
• Dr. Anuradha P. Prajapati
• Dr. Sachin B. Narkhede

The given study describes the formulation of nanoparticles and its delivery in the form of nanoparticles. Olanzapine is one of the most prescribed drug for the treatment of Schizophrenia. It belongs to 2nd generation antipsychotics. Olanzapine belongs to BCS class II and possess low solubility, So the aim of this study was to formulate and optimise the agglomerates of Olanzapine with enhanced solubility and dissolution characteristics. The Quasi Emulsion Solvent Diffusion Technique was used to prepare drug loaded agglomerates. The method involves use of the internal phase consisting of the good solvent and the external phase consisted of bridging liquid and poor solvent and the polymer. Process variables were evaluated and preliminary screening was carried out in concern to preparation of the agglomerates. Evaluation of the factorial batches was carried out like microscopy study, percentage yield, drug content, Micromeritic properties etc. The results indicates that Olanzapine was highly dispersed in agglomerates. Further the agglomerates were evaluated for parameters like FTIR, Drug content, Percentage yield and Dissolution. The prepared agglomerates were compressed in the form of Sublingual Tablet. Finally it was concluded that the formulated agglomerates have good dissolution characteristics as compared to that of pure drug as well as marketed formulation.

Nanoparticles, Quasi Emulsion Solvent Diffusion Technique, Crospovidone, Nanoparticulate Sublingual Tablet.

"Development And Evaluation Of Nanoparticulate Sublingual Tablet Of Olanzapine", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 5, page no.b155-b164, May-2021, Available :http://www.jetir.org/papers/JETIR2105147.pdf

"Development And Evaluation Of Nanoparticulate Sublingual Tablet Of Olanzapine", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 5, page no. ppb155-b164, May-2021, Available at : http://www.jetir.org/papers/JETIR2105147.pdf