UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 8 Issue 5
May-2021
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2105455


Registration ID:
309403

Page Number

d489-d509

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Title

Synthesis of substituted 6, 7-dimethoxy-4-(3, 4, 5-trimethoxyphenyl)-3, 4-dihydronaphthalen-1(2H)-one and their Apoptosis study

Abstract

The field of biomedical analogs of podophyllotoxin is more in its infancy, but the explosion of interest in these molecules as inherently active therapeutic agents is increasing. There is growing interest in the design and synthesis of novel biocompatible analogs. The series of novel substituted podophyllotoxin derivatives were synthesized under mild conditions with satisfactory yield. Auto dock server analysis of the these analogs structure showed that the compounds were shown to interact with the proteins involved in Bcl-xL mediated pathway with inhibition constant of 0.000149 and 0.000584 for 5G and 5C respectively The recorded results of lipid peroxidation with treated samples were increasing with increasing concentration.

Key Words

Podophyllotoxin,tetralone docking study, ETA cell Tryphan blue assay, Auto dock,.

Cite This Article

"Synthesis of substituted 6, 7-dimethoxy-4-(3, 4, 5-trimethoxyphenyl)-3, 4-dihydronaphthalen-1(2H)-one and their Apoptosis study", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 5, page no.d489-d509, May-2021, Available :http://www.jetir.org/papers/JETIR2105455.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"Synthesis of substituted 6, 7-dimethoxy-4-(3, 4, 5-trimethoxyphenyl)-3, 4-dihydronaphthalen-1(2H)-one and their Apoptosis study", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 5, page no. ppd489-d509, May-2021, Available at : http://www.jetir.org/papers/JETIR2105455.pdf

Publication Details

Published Paper ID: JETIR2105455
Registration ID: 309403
Published In: Volume 8 | Issue 5 | Year May-2021
DOI (Digital Object Identifier):
Page No: d489-d509
Country: Mysure, karnataka, India .
Area: Chemistry
ISSN Number: 2349-5162
Publisher: IJ Publication


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