• Suraj Maurya
• Manoj Kumar Yadav
• Piyush Yadav
• Shashikant Maury
• Ravikant Vishwakarma

The process of designing new drugs with the aim of enhancing existing ones is referred to as "drug design." The synthesis of biologically active compounds based on naturally occurring drugs, and the synthesis of structural analogues of naturally occurring lead molecules are all examples of random screening of synthetic compounds and the application of the bioisosteric principle are only a few of the techniques that have been used. As a result, the most recent trend in drug development is to either completely reinvent a lead or optimise an established lead. Lead chemical structure can be used to make chemical alterations to improve potency, selectivity, or pharmacokinetic properties. Furthermore, freshly developed pharmacologically active moieties may lack drug-like properties, necessitating chemical modification before being studied physiologically or therapeutically. While computer-aided drug design is still in its infancy, it is projected to play a considerably larger role in the near future, given the many astonishing breakthroughs made in recent years.

Lead compound, CADD, Optimization, Pharmacophore, Active moieties, Software

"Lead Compound: Approaches of CADD", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 5, page no.e499-e503, May-2021, Available :http://www.jetir.org/papers/JETIR2105604.pdf

"Lead Compound: Approaches of CADD", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 5, page no. ppe499-e503, May-2021, Available at : http://www.jetir.org/papers/JETIR2105604.pdf