• Trupti.S. Chite
• Shubhangi Kumbhar
• Rasika Mulik
• Sadeecha Wani
• Rutuja Pawar, Sheetal Parse,Pooja Wagh

Abstract: Aim of the present work was to synthesize some triazole and thiadiazole derivatives and evaluate them for their Anti-tubercular activity. Six triazole-thiadiazole hybrid derivatives were synthesized, subjected to docking studies and evaluated for their anti-tubercular activity using XTT Reduction Menadione Assay Protocol. The compounds , 5E viz.,3-(3-nitrophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6(5H)-thione and 5F, 3-(2,4-dichlorophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6(5H)-thione have shown better activity as compared to other derivatives. The 5E has shown better docking score as compared to the standard used. Hybrids of triazole and thiadiazole thus can be further explored.

Index Terms: Antitubercular, Triazole- Thiadiazole Hybrid, DNA gyrase, XTT Assay, Molecular Docking

"SYNTHESIS, DOCKING AND ANTITUBERCULER ACTIVITY OF TRIAZOLE-THIADIAZOLE HYBRIDE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 5, page no.e780-e787, May-2021, Available :http://www.jetir.org/papers/JETIR2105636.pdf

"SYNTHESIS, DOCKING AND ANTITUBERCULER ACTIVITY OF TRIAZOLE-THIADIAZOLE HYBRIDE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 5, page no. ppe780-e787, May-2021, Available at : http://www.jetir.org/papers/JETIR2105636.pdf