• Aswathy P.M
• Nagaraj S
• Sri Naveenchandra N. H

The concept of ama is unique in Ayurveda and is considered as the root cause of various disorders. Amavata is characterised by ruja and shopha, predominantly in sandhi. Thus this disease shows the classical signs of inflammation with both systemic and articular manifestations. Inflammation is associated with systemic reactions that are collectively called acute phase response, which is mediated by cytokines like TNF alpha, IL-1 and IL-6. In response to this reaction liver synthesizes acute phase proteins like C - reactive protein (CRP) and Fibrinogen irritates rouleaux formation leading to a rapid Erythrocyte Sedimentation Rate (ESR). In this present study an attempt is made to assess the fluctuation of inflammatory markers during various avasthabhedas of the disease. Objectives: The present study is to assess the probable changes in inflammatory markers like ESR, CRP and TNF- alpha in Amavata. Methods: This is a cross-sectional observational study with 30 patients diagnosed with Amavata based on Ayurvedic classics according were selected for the study. A special proforma was prepared with all points of history taking, physical signs and symptoms as mentioned in our classics including laboratory investigations. Analysis of recorded data was done by descriptive statistics. Results: In this study majority of patients with severe pratyatma lakshanas of Amavata were having raised ESR, CRP and TNF alpha values. Conclusion: Based on the observational study carried out in 30 patients with Amavata, it can be concluded that with increase in the severity of Amavata lakshanas and according to various avasthabhedas of Amavata there was an increase in the level of inflammatory markers.

Amavata, ESR, TNF- alpha, IL-1, IL-6, CRP, avasthabhedas

" AN OBSERVATIONAL STUDY ON AMAVATA W.S.R. TO CHANGES IN INFLAMMATORY MARKERS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 6, page no.d586-d592, June-2021, Available :http://www.jetir.org/papers/JETIR2106487.pdf

" AN OBSERVATIONAL STUDY ON AMAVATA W.S.R. TO CHANGES IN INFLAMMATORY MARKERS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 6, page no. ppd586-d592, June-2021, Available at : http://www.jetir.org/papers/JETIR2106487.pdf