• SANTHOSH KUMAR T S
• Mrs. AKKAMMA H G
• Dr. C SRIDHAR
• T SRINIVAS RAO

Objective: To develop a simple and accurate RP-HPLC method for estimation of Dexlansoprazole, proposed method was validated according to an International Conference on Harmonisation of technical requirements for registration of pharmaceuticals for human use (ICH) guidelines. Methods: The column used for method development of Dexlansoprazole was Hypersil-BDS, C18, 250*4.6 mm, 5µ. Methanol and Acetonitrile were used in the ration of 60:40 for the method development and is used as mobile phase in gradient composition at a flow rate of 1.0 ml/min. UV detection was made at 283 nm. The developed method was validated for various parameters such as specificity, linearity, range, accuracy, precision, system suitability, robustness, ruggedness etc. Results: The result obtained in this study demonstrated that the RP-HPLC method described is specific, accurate, precise, linear, ruggedness, robustness, stability, LOD and LOQ indicating for the determination of Dexlansoprazole. Conclusion: Proposed method is specific, precise, sensitive, linear and accurate

Dexlansoprazole, HPLC,Method Development.

"ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF DEXLANSOPRAZOLE BY RP-HPLC METHOD IN BULK AND PHARMACEUTICAL DOSAGE FORM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 6, page no.f882-f889, June-2021, Available :http://www.jetir.org/papers/JETIR2106824.pdf

"ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF DEXLANSOPRAZOLE BY RP-HPLC METHOD IN BULK AND PHARMACEUTICAL DOSAGE FORM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 6, page no. ppf882-f889, June-2021, Available at : http://www.jetir.org/papers/JETIR2106824.pdf