• Kavya Parnami
• NA
• NA
• NA
• NA

In a spunk against cancer, Enzymo-therapy has emerged as one of the most effective strategy recently. Resistance to conventional anticancer therapies in patients with advanced solid tumors has prompted the need for alternative cancer therapies. Delving into novel pharmacological tools is one priority area of research in cancer biology due to the inefficiency of the existing therapeutic approaches toward this disease. Moreover, the success of novel cancer therapies depends on their selectivity for cancer cells with limited toxicity to normal tissues. L-methioninase enzymatic approach has shown considerable beneficial effects in reducing cancer burden in experimental models. L-Methioninase (MGL) has received much attention in the recent years, since it shows antiproliferative activity and methionine restriction has been known to arrest tumor growth. Methionine dependence is the only known general metabolic defect in cancers. Methionine is an essential amino acid necessary for normal growth and development in mammals. Normal cells have the ability to grow on homocysteine, instead of methionine, due to their active methionine synthase. Many human cancer cell lines and primary tumors have an absolute requirement for L-methionine, an essential amino acid. Thus, depleting cellular/plasma methionine levels using MGL seems to be a promising therapeutic approach to treat cancer. The present article is a brief attempt to witness the structure, prominent sources and mechanism of action of L-methioninase. It also catalogues the role of L-methioninase on tumor cells and highlights its future prospects.

L-Methioninase, Enzymo-therapy, anticancer, review

"L-Methioninase: A cogent Anticancer tool", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 7, page no.b99-b103, July-2021, Available :http://www.jetir.org/papers/JETIR2107142.pdf

"L-Methioninase: A cogent Anticancer tool", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 7, page no. ppb99-b103, July-2021, Available at : http://www.jetir.org/papers/JETIR2107142.pdf