UGC Approved Journal no 63975

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 8 Issue 7
July-2021
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2107452


Registration ID:
312563

Page Number

d469-d474

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Title

Synthesis of biologically active nitrogen heterocycles as potential anti-malarial

Abstract

The study of heterocyclic compounds has attracted the attention of chemists very earlier and continues ever, producing a plethora of new compounds. Moreover, heterocyclic compounds were not only attracting the attention of organic chemists but also pharmacists and biologists in view of their interesting pharmacological potentials. Among the heterocycles, nitrogen containing heterocyclic compounds such as indoles, benzo analog carbazoles, quinolines, its benzo-analog acridine are some of the important structural components in alkaloids and in many pharmaceutical agents. Vector control is a serious concern in developing countries, every year a large part of the population in the world is affected by one or more vector borne diseases, such as malaria, filaria, dengue etc., Malaria is life-threatening disease, predominant across 92 countries resulting in over a 3.4 billion people being infected annually; research to develop new antimalarial drugs have drastically increased over past 10 years. Quinoline derivatives such as Chloroquine, Mefloquine, Primaquine, Tafenoquine are widely used to fight against malaria. Chloroquine (CQ), the most widely used antimalarial drug, is an acidotropic agent which accumulates to high levels in malaria-infected erythrocytes.

Key Words

Plasmodium Falciparum, antiplasmodial, carbazole, indole, quinoline, IC50

Cite This Article

"Synthesis of biologically active nitrogen heterocycles as potential anti-malarial", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 7, page no.d469-d474, July-2021, Available :http://www.jetir.org/papers/JETIR2107452.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"Synthesis of biologically active nitrogen heterocycles as potential anti-malarial", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 7, page no. ppd469-d474, July-2021, Available at : http://www.jetir.org/papers/JETIR2107452.pdf

Publication Details

Published Paper ID: JETIR2107452
Registration ID: 312563
Published In: Volume 8 | Issue 7 | Year July-2021
DOI (Digital Object Identifier):
Page No: d469-d474
Country: Bangalore, KARNATAKA, India .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication


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