• Devarapogu Rajakumari
• A. Usha Rani

The protective effects of zinc on cadmium toxicity were investigated in this study, with a focus on oxidative enzyme levels in the zebrafish liver and blood biochemical parameters of cadmium, zinc, and cadmium + zinc treated zebrafishes. We observed synergetic effects of zinc on reducing cadmium toxicity in all of the parameters we studied. The effectiveness of zinc treatment in lowering cadmium toxicity was demonstrated by the growth and survival rate of zebrafish subjected to cadmium. Results have proved that the zinc treatment has increased the survival percentage along with body weight and length. When zebrafish were administered cadmium, the oxidative enzyme succinate dehydrogenase (SDH) in the liver homogenate reduced drastically, from 6.86 mU/mg (control) to 2.73 mU/mg (cadmium treated). However, when cadmium and zinc were given simultaneously, the SDH incidence increased (4.97 mU/mg). Similar pattern was observed in other tested enzymes. Hematological properties of treated fish blood clearly indicate that zinc has the capability in reducing cadmium toxicity. To summarize, the findings show that even modest doses of cadmium are hazardous to zebrafish and cause changes in hematological and oxidative enzyme levels. Lower doses of zinc, on the other hand, can significantly diminish cadmium's detrimental effects.

Cadmium, Zinc, Toxicity, Oxidative enzymes, Blood Biochemistry

"EFFECTS OF ZINC IN REDUCING CADMIUM TOXICITY WITH SPECIAL REFERENCE TO OXIDATIVE ENZYME LEVELS AND HEMATOLOGICAL PARAMETERS IN ZEBRAFISH (DANIO RERIO)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 7, page no.e365-e370, July-2021, Available :http://www.jetir.org/papers/JETIR2107555.pdf

"EFFECTS OF ZINC IN REDUCING CADMIUM TOXICITY WITH SPECIAL REFERENCE TO OXIDATIVE ENZYME LEVELS AND HEMATOLOGICAL PARAMETERS IN ZEBRAFISH (DANIO RERIO)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 7, page no. ppe365-e370, July-2021, Available at : http://www.jetir.org/papers/JETIR2107555.pdf