• Krishna Viradiya

The frequency of recurrence of the immunoglobulin-like receptor (KIR) gene, changes in the period of time in the middle of the population, depending on the functional disorders of the immune system's responses to viruses, autoimmune diseases, and reproductive success. KIR (Killer Immunoglobulin-like Receptor) variants influence immune responses and are genetic factors in disease susceptibility. This study describes the frequency distribution of the 12-variable KIR genes and their HLA-C ligands in two of the Iranian people, who have lived for generations in a variety of environments such as Azerbaijanis, at a great height, and the people of the sea level. The results are compared with those published for other populations, and a wide range of English Terms. Differences were observed in the frequency of HLA-C groups and KIR and the linkage disequilibrium, and the proportion of activating / inhibitory KIR between the two groups. The association with a geographical, similar to populations in the frequencies of the KIR A and B) and the KIR AA genotype, go back to their common origin. The variability of the KIR gene family and their HLA-C ligands has been observed, as well as their importance for the determination of the differences between geographically and culturally isolated communities, and to be subject to various kinds of pollution in the environment, and drawn from the same ethnic group.

Immunoglobulin-like receptor (KIR), Human leukocyte antigen HLA-C, NK cells, Decidual natural killer (dNK) cell, Embryo implantation, pre-eclampsia.

"“A Mini Review on Immunological aspects of Embryo Implantation: Role of NK cells, Killer immunoglobulin and HLA-C”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 7, page no.e779-e795, July-2021, Available :http://www.jetir.org/papers/JETIR2107603.pdf

"“A Mini Review on Immunological aspects of Embryo Implantation: Role of NK cells, Killer immunoglobulin and HLA-C”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 7, page no. ppe779-e795, July-2021, Available at : http://www.jetir.org/papers/JETIR2107603.pdf