UGC Approved Journal no 63975

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 8 Issue 7
July-2021
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2107728


Registration ID:
313321

Page Number

f979-f990

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Title

INHIBITORY MECHANISM OF SOLANUM XANTHOCARPUM FRUIT IN MCF-7 BREAST CANCER CELL LINE

Abstract

Medicinal plants from a large group of economically important plants that provide the basic raw materials for indigenous pharmaceuticals. The medicinal value of plants lies in some chemical substances that produce a definite physiologic action on the human body. The cytotoxicity studies using different dyes showed great anticancer potential of the fruit extract of Solanum xanthocarpum. Viability of cells measured by MTT assay, SRB assay and nuclear fragmentation. The percentage viability of MCF-7 line cells was considerably decreased with the increasing concentration of the extracts in MTT assay, SRB assay and nuclear fragmentation. These results imply that higher contents of bioactive compound and antioxidant potential of Solanum xanthocarpum fruit extracts can possibly act as chemopreventive agents with respect to inhibition of the growth of breast cancer cells through the induction of apoptosis. In our study , caspase 3 activity of ethonolic extract of Solanum xanthocarpum revealed that in the expression of caspase 3, the drug induced only about 12% to 15% caspase 3 expression when compared to the expression rate in untreated cells.

Key Words

Solanum Xanthocarpum, MTT assay, SRB assay, Caspase 3, Nuclear Fragmentation.

Cite This Article

"INHIBITORY MECHANISM OF SOLANUM XANTHOCARPUM FRUIT IN MCF-7 BREAST CANCER CELL LINE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 7, page no.f979-f990, July-2021, Available :http://www.jetir.org/papers/JETIR2107728.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"INHIBITORY MECHANISM OF SOLANUM XANTHOCARPUM FRUIT IN MCF-7 BREAST CANCER CELL LINE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 7, page no. ppf979-f990, July-2021, Available at : http://www.jetir.org/papers/JETIR2107728.pdf

Publication Details

Published Paper ID: JETIR2107728
Registration ID: 313321
Published In: Volume 8 | Issue 7 | Year July-2021
DOI (Digital Object Identifier):
Page No: f979-f990
Country: coimbatore, TamilNadu, India .
Area: Science
ISSN Number: 2349-5162


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