UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 8 Issue 8
August-2021
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

7.95 impact factor calculated by Google scholar

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Published Paper ID:
JETIR2108083


Registration ID:
313337

Page Number

a629-a661

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Title

Impact of Different Pharmacological Treatments on Outcomes in Adult Rats after Traumatic Brain Injury: A Systematic Review and Meta-analysis

Abstract

Many pharmacological interventions have been developed to treat Traumatic brain injury and its alterations. Many interventions have been investigated pre clinically to evaluate their effects on motor, cognition and behavioural functioning following Traumatic Brain injury. But, most of these studies have not been able to provide sufficient conclusions regarding the efficacy of these drugs mostly due to their small sample sizes. So, a systematic review and meta-analysis (1990-2020) was conducted to examine the effects of pharmacological interventions in rodents after traumatic brain injury on functional outcomes. The PubMed database searches were conducted using 56 key terms. Weighted mean effect sizes, percent overlap, fail-safe (Nfs) and confidence intervals were calculated for the interventions. Total, 125 interventions were evaluated in 285 preclinical studies using 51 activities. Interventions investigated by multiple studies and with great treatment benefits were majorly focused. Out of all the interventions, 42 improved the cognitive outcomes, 44 improves motor and 6 improved the behavioural functioning. The treatment benefits were majorly affected by drug dosage and treatment intervals used in the studies.

Key Words

Traumatic brain injury, Traumatic brain injury models, Weight drop model, Pharmacological interventions, Neurotrauma.

Cite This Article

"Impact of Different Pharmacological Treatments on Outcomes in Adult Rats after Traumatic Brain Injury: A Systematic Review and Meta-analysis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 8, page no.a629-a661, August-2021, Available :http://www.jetir.org/papers/JETIR2108083.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"Impact of Different Pharmacological Treatments on Outcomes in Adult Rats after Traumatic Brain Injury: A Systematic Review and Meta-analysis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 8, page no. ppa629-a661, August-2021, Available at : http://www.jetir.org/papers/JETIR2108083.pdf

Publication Details

Published Paper ID: JETIR2108083
Registration ID: 313337
Published In: Volume 8 | Issue 8 | Year August-2021
DOI (Digital Object Identifier):
Page No: a629-a661
Country: Kapurthala, Punjab, India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication


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