• Shamima Nasreen Ahmed
• DEEPAK KUMAR JHA
• SUMAN SAMADDAR

Background: Cancer can be stated as one of the most deadly disease all around the world. Second leading cause of death in the world. Chemotherapy and anti cancer drugs are use to kill cancerous cells in the body. Among all the different side effects of chemotherapeutic drugs peripheral neuropathy is the most common and dose-limiting side effect. Objectives: This study aims to assess the protective effect of the flavonoid rutin based on its anti oxidant property against paclitaxel induced peripherial neuropathy in male wister rats. Rutin has been described as cell protecting agents because of its anti-oxidant, antinociceptive and anti inflammatory actions. Method: Paclitaxel (1mg/kg, i.p) was injected to male wister rat on four alternate days (0,2,4 and 6). The development of sensory alterations were evaluated by various in vivo methods- muscle grip test, acetone spray test, hot plate method, and tail flick method. Rutin (30mg/kg orally) dissolved in water was administered for 14 days with a single dose of paclitaxel on the 10th day. The animal’s sciatic nerve were removed for histopathological evaluation and blood serum was collected for the assessment of antioxidant property. Result: The thermal and mechanical nociceptive response was significantly increase by paclitaxel which was prevented or reduced by rutin at all dose. Nerve degradation, axonal derangement and shrinkage, epineurium deranged, perineurium abnormality and myelin sheath damaged showed paclitaxel induced peroxidation in the scatic nerve and that rutin decreases this effect. Also the flavonoid decreases inducible nitric oxcide synthase and increase catalase in the blood serum. Conclusion: In this study it was observed that paclitaxel induced painful peripheral neuropathy in rats was prevented by the flavonoid rutin. The mechanism of pactitaxel- chemotherapeutic drug appears to be at least oxidative stress induced that showed neumerous neuronal damage with increase vascular edema, vascular changes etc in the sciatic nerve of the neuropathy induction group.

Keywords: Paclitaxel, Rutin, antinociceptive, scatic nerve, peripheral neuropathy.

"EVALUATION OF NEUROPROTECTIVE POTENTIAL OF RUTIN AGAINST PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY IN RATS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 8, page no.b238-b248, August-2021, Available :http://www.jetir.org/papers/JETIR2108160.pdf

"EVALUATION OF NEUROPROTECTIVE POTENTIAL OF RUTIN AGAINST PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY IN RATS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 8, page no. ppb238-b248, August-2021, Available at : http://www.jetir.org/papers/JETIR2108160.pdf