• MAGD GAMIL ALSHARGABI
• Deepak Kumar JHA

Background: Herbal drugs play an important role in health care, especially in developing countries. Momordica (M.) dioica (family Cucurbitaceae) is a climbing creeper and reported as an important medicinal herb since ancient times for various conditions. In India, fruits of M. dioica are used as a folk remedy for Diabetes mellitus. Objective: In this study, methanolic extract of M. dioica (MtEMD) fruits was investigated for its protective effects against L-Arginine (Arg)-induced pancreatitis in rats. Methods: Normal control group received vehicle orally (p.o), daily, low-dose and high dose test groups was treated with MtEMD daily (p.o) at 250 mg/kg and 500 mg/kg respectively. Standard group received 30mg/kg Methylprednisolone (MP), (p.o), daily. The treatment period was 21 days. Acute pancreatitis (AP) was induced on the 18th day of the treatment by two intraperitoneally (i.p.) injections of 250 mg/100 g body wt. of Arg as a 20% solution in 0.15 M saline at an interval of 1 h. Protective effects of MtEMD on Arg-induced pancreatitis in rats were determined for biochemical parameter of serum, various antioxidant enzymes, and histopathological damages in pancreas. Results: MtEMD-pretreated groups showed dose dependent significant (p < 0.05) reduction in pancreatic nitrate and lipid peroxidation (LPO) levels compared to disease group. MtEMD pretreatment also resulted a significant (p < 0.05) increase in pancreatic contents of protein, GSH concentration, and activity of superoxide dismutase (SOD) and catalase (CAT) with amelioration of histological changes of test groups as well as standard group. Conclusion: MtEMD pretreatment results in a protective effect comparable with that of MP pretreatment in AP rat model.

Momordica dioica, Acute Pancreatitis, Arginine-Induced Pancreatitis.

"PHARMACOLOGICAL EVALUATION OF METHANOLIC EXTRACTION OF FRUITS OF MOMORDICA DIOICA ON L-ARGININE INDUCED PANCREATITIS IN RATS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 8, page no.c170-c180, August-2021, Available :http://www.jetir.org/papers/JETIR2108275.pdf

"PHARMACOLOGICAL EVALUATION OF METHANOLIC EXTRACTION OF FRUITS OF MOMORDICA DIOICA ON L-ARGININE INDUCED PANCREATITIS IN RATS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 8, page no. ppc170-c180, August-2021, Available at : http://www.jetir.org/papers/JETIR2108275.pdf