• Jahangir Hussain Khan
• R.K patil
• Aitisam Farooq Shah
• Nitin Bansal

Osteoarthritis is one of the most prevalent disorders in the world. It is characterized as deterioration of articular cartilage, intraarticular inflammation, change in Pariarticular and subchondral bone. The prevalence of osteoarthritis in India is 27-28 %. Osteoarthritis involves many joints hip joint, knee joint, spine facet joint, interphalangeal joints, CMC joints. Alteration in chondrocytes and Extracellular matrix homeostasis mechanism, cartilage destruction, activation of inflammatory mediators, Interleukins, metalloproteinase, collagenase. Some genes are also involved. Assessment of Osteoarthritis is done by assessing pain in joints, age, narrow joint space, radiographic imaging. Various drugs to be used for the treatment of degenerative joint disease include NSAIDs, opioids, acetaminophen. Apart from corticosteroid injections, serotonin reuptake inhibitors, some dietary supplements are also used

Osteoarthritis, Pathophysiology, Genes, Diagnose criteria, Management

"OSTEOARTHRITIS: PATHOPHYSIOLOGY, DIAGNOSE, MANAGEMENT AN OVERVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 8, page no.c181-c187, August-2021, Available :http://www.jetir.org/papers/JETIR2108276.pdf

"OSTEOARTHRITIS: PATHOPHYSIOLOGY, DIAGNOSE, MANAGEMENT AN OVERVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 8, page no. ppc181-c187, August-2021, Available at : http://www.jetir.org/papers/JETIR2108276.pdf