• Somnath Rasane
• Hemlata Bhavar
• Sagar Magar

The present study describes a simple, accurate, precise and cost-effective reverse phase High Performance Liquid Chromatographic method for estimation of tenoxicam in their pharmaceutical dosage form. The separation was carried on Kromasil, C18, 250 mm X 4.6 mm, 5 µm. Detection was done using UV detector at isocratic point 368 nm. The developed method employed mobile Acetonitrile: Buffer (60: 40 % v/v), with flow rate 1.0 ml/min. High linearity of the developed method was confirmed over concentration range 1-8 µg/ml for tenoxicam with the correlation coefficient of 0.999. The Percentage RSD for precision of the method was found to be less than 2%. The percentage recoveries for tenoxicam was found to be in range 98.00-102.00 w/v. Peaks was obtained at retention time 2.9 min for for tenoxicam. By using all the above parameters, a simple, accurate, precise and cost-effective method were developed, optimize and validate.

RP-HPLC, Method optimization , development, tenoxicam .

"“DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF TENOXICAM IN ITS BULK AND PHARMACEUTICAL DOSAGE FORM.”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 8, page no.c235-c251, August-2021, Available :http://www.jetir.org/papers/JETIR2108282.pdf

"“DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF TENOXICAM IN ITS BULK AND PHARMACEUTICAL DOSAGE FORM.”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 8, page no. ppc235-c251, August-2021, Available at : http://www.jetir.org/papers/JETIR2108282.pdf