• Zionmit Lepcha
• Deepak Kumar Jha

Background: Natural products have played a huge role in the evolution of pharmaceuticals and agrichemicals which has helped amplify the welfare of living beings since centuries. Marine Kingdom is distinguished in terms of potential organisms with profuse sources of vast and diverse biologically potent compounds. Symphyocladia latiuscula (Yamada), a red marine alga belonging to the family Rhodomelaceae, from the order Ceramiales, found in the banks of North China, Japan and Korea has shown promising therapeutic potential in the treatment of various diseases. Objectives: In this study, investigation of the protective potential of the polyphenols of red marine alga Symphyocladia latiuscula (SL) in rats with pancreatic dysfunction induced by poloxamer-407 and free fatty acid was carried out. Methods: Normal control group received vehicle orally (p.o), daily, the disease group received co-administration of Poloxamer-407 (10 mg/kg) i.p and FFA (palmitic acid - 200 mg/kg, twice a day, i.p) for 5 weeks, daily to induce pancreatic dysfunction, the treatment group received disease control + Symphyocladia latiuscula polyphenols (200 mg/kg) p.o for 4 weeks and the standard group received disease control + metformin (100 mg/kg) p.o for 4 weeks. The blood glucose was monitored biweekly. Protective effects of Symphyocladia latiuscula on Poloxamer-407 and P.A induced pancreas dysfunction in rats were determined by various in vivo and in vitro models - Fasting and post-prandial glucose, Sucrose-preference test, Glucose tolerance test, Insulin tolerance test, Insulin Assay, Homeostasis Model of Insulin Resistance (HOMA-IR), biochemical parameters of serum, various antioxidant enzymes, and histopathological damages in pancreas. Results: The S. latiuscula exhibited significant reduction in fasting and post prandial blood glucose, sucrose preference, total cholesterol, triglycerides, LDL, VLDL, HbA1c, Superoxide dismutase, Malondialdehyde, Nitric oxide, improvement of insulin production, glucose tolerance, insulin tolerance, HOMA-IR; increase in HDL and glutathione levels in the treated group and amelioration of histological changes of test groups as well as standard group as compared to the disease group. Conclusion: Symphyocladia latiuscula treatment showed a protective and comparable effect with metformin treatment in pancreas dysfunction rat model.

Symphyocladia latiuscula, pancreatic dysfunction

"EVALUATION OF PROTECTIVE EFFECT OF THE POLYPHENOLS OF RED MARINE ALGA SYMPHYOCLADIA LATIUSCULA AGAINST POLOXAMER-407 AND FREE FATTY ACID-INDUCED PANCREAS DYSFUNCTION ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 8, page no.c735-c750, August-2021, Available :http://www.jetir.org/papers/JETIR2108344.pdf

"EVALUATION OF PROTECTIVE EFFECT OF THE POLYPHENOLS OF RED MARINE ALGA SYMPHYOCLADIA LATIUSCULA AGAINST POLOXAMER-407 AND FREE FATTY ACID-INDUCED PANCREAS DYSFUNCTION ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 8, page no. ppc735-c750, August-2021, Available at : http://www.jetir.org/papers/JETIR2108344.pdf