• Khandre Rajeshree
• DR. S. R. LAHOTI

The objective of this investigation was to study the effect of cocrystallization with different cocrystal formers on physicochemical properties of Atorvastatin calcium. Pharmaceutical co-crystal is more thermodynamically stable than crystal form of drugs. Cocrystals were prepared by liquid assisted grinding method with Atorvastatin and different cocrystal formers. The pure drug and the prepared cocrystals were characterized in terms of saturation solubility, infrared spectroscopy, differential scanning calorimetry. Co-crystallization alters the molecular interactions and composition of pharmaceutical materials, and is considered better alternative to optimize drug properties. In the present investigation an attempt has been made to enhances solubility of poorly soluble drug by formulating co-crystals. The Hansen solubility approach was successful for predicting the Atorvastatin calcium Co-crystals. The increase in the aqueous solubility and physicochemical property of insoluble and slightly soluble drugs is of major concern in pharmaceutical formulations. Cocrystals not only provide a technique for improvement of physiochemical property but also provide opportunity to the researchers of pharmaceutical companies regarding intellectual property. Melting point, DSC, FTIR spectra of co-crystals were different than pure drug and co-formers indicating their interaction. XRD patterns of co-crystals were not completely amorphous but less intense compared to drug alone.

Cocrystals; liquid assisted grinding

"Solubility Enhancement Of Atorvastatin By Co-Crystallization Technique", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 8, page no.c838-c862, August-2021, Available :http://www.jetir.org/papers/JETIR2108356.pdf

"Solubility Enhancement Of Atorvastatin By Co-Crystallization Technique", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 8, page no. ppc838-c862, August-2021, Available at : http://www.jetir.org/papers/JETIR2108356.pdf