UGC Approved Journal no 63975(19)

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Published in:

Volume 8 Issue 8
August-2021
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2108414


Registration ID:
314201

Page Number

d349-d358

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Title

GC-MS Characterization and Molecular docking analysis of candidate compounds derived from aqueous extract of seed of Phaseolus vulgaris L. to identify anti-Diabetic potential

Abstract

Herbal drugs are used for the treatment of diseases and disorders with its less side effects, easy availability and low cost. Several bioactive compounds have been isolated from aqueous extract of seed of Phaseolus vulgaris L. and were taken for screening. This study aimed to evaluate molecular interactions of selected diabetes mellitus (DM) targets with bioactive compounds isolated from aqueous extract of seed of Phaseolus vulgaris L. In this article, screening of the best substances as bioactive compounds is achieved by molecular docking analysis with selected DM target proteins i.e., aldose reductase (AR). In this study, five phytochemicals of aqueous extract of seed of Phaseolus vulgaris L. were selected from GC- MS (5,12- Naphathacenequinone, 4- Isopropylbenzyl alcohol, Decanoic acid, 1,4- Benzenedicarboxylic acid, and 1,4- Dimethoxybenzene) were analyzed for the inhibition activity against Aldose Reductase (1US0) receptor of anti-diabetic activity using. The binding energy for each compound was chosen with the targets using AutoDock 4.2. The binding energy of -11.21, -4.99kcal/mol all values was shown for bioactive compound. Out of five compounds, 5, 12-naphathacenequinone, and 4-isopropylbenzyl alcohol were observed as most suitable ligands for management of diabetes mellitus.

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"GC-MS Characterization and Molecular docking analysis of candidate compounds derived from aqueous extract of seed of Phaseolus vulgaris L. to identify anti-Diabetic potential", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 8, page no.d349-d358, August-2021, Available :http://www.jetir.org/papers/JETIR2108414.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"GC-MS Characterization and Molecular docking analysis of candidate compounds derived from aqueous extract of seed of Phaseolus vulgaris L. to identify anti-Diabetic potential", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 8, page no. ppd349-d358, August-2021, Available at : http://www.jetir.org/papers/JETIR2108414.pdf

Publication Details

Published Paper ID: JETIR2108414
Registration ID: 314201
Published In: Volume 8 | Issue 8 | Year August-2021
DOI (Digital Object Identifier):
Page No: d349-d358
Country: Erode , Tamilnadu , India .
Area: Biological Science
ISSN Number: 2349-5162
Publisher: IJ Publication


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