• D.Siva nagaraju
• Dr.J.N.Suresh kumar
• D.venkata silpa
• G.venkata navya lakshmi
• T.Leela manasa,G.Sindhu sravanthi,G.Subbalakshmi

The objective of the present study was to develop Glimepiride floating microspheres in order to achieve an extended retention in the upper GIT, which enhances the absorption and improves the bioavailability. The microspheres were prepared by emulsion solvent diffusion-evaporation method using different ratios of rate controlling polymers ethyl cellulose and hydroxy propyl methyl cellulose, Glimepiride is used in each formulation at constant ratio. The mixture of dichloromethane and ethanol at ratio of (1:1), with tween 80 as the surfactant. The prepared microspheres were evaluated for percentage yield, particle size, entrapment efficiency, shape and surface characterization, buoyancy, in vitro dissolution studies and drug release mechanismwas interpretated by kinetic model. The effect of polymer concentration on these parameters was investigated. The studies revealed that increase in concentration of hydrophilic polymer (HPMC) increased the drug release from the floating microspheres. The formulation F9 (Glimepiride: HPMC:EC is 1:3:2) was selected as best formulation, and it follows zero order drug release with 86.63% entrapment efficiency, 98.16% drug content, 90% buoyancy, 87.48%In-vitro drug release at 12th hour.

The study showed that Glimepiride floating microspheres can be developed by Emulsion solvent diffusion-evaporation method and the results revealed that the formulation F9 shows desired release characterstics in the polymer ratio of (3:2) the hydroxy propyl methyl cellulose and ethyl cellulose in order to achieve the controlled release of drug up to 12 hours. Further in- vivo studies to be carried out to confirm the formulation

"FORMULATION AND EVALUATION OF GLIMEPIRIDE FLOATING MICROSPHERES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 9, page no.d767-d786, September-2021, Available :http://www.jetir.org/papers/JETIR2109387.pdf

"FORMULATION AND EVALUATION OF GLIMEPIRIDE FLOATING MICROSPHERES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 9, page no. ppd767-d786, September-2021, Available at : http://www.jetir.org/papers/JETIR2109387.pdf