• SHESHARAO
• Suguna rao
• Manjunatha
• Sathyanarayan
• Byregowda

The alcoholic extract of Trigonella foenum graecum seed extract (1 gm/kg b w / day) and Trigonella foenum graecum seed extract with glibenclamide half dose were tested for its pathomorphological effects in streptozotocin induced diabetes in rats. Streptozotocin produced diabetes effectively in all the animals at 45 mg/kg in citrate buffer intraperitonially with a significant increase in beta cell whereas, Trigonella foenum graecum seed extract alone and in combination with glibenclamide half dose treated rats showed significant improvement in structure of beta cell its morphology. Trigonella foenum graecum seed extract alone and in with glibenclamide half dose also alleviated the damage caused by STZ morphologically in beta cells of islets of Langerhans and hepatocytes. The efficacy of Trigonella foenum graecum in rats individually as well as in combination with the half dose of glibenclamide was evaluated and observed synergistic effect between Trigonella and glibenclamide.

Key words: Diabetes, Trigonella foenum graecum, streptozotocin

"PATHOMORPHOLOGICAL EVALUATION OF ANTIDIABETIC EFFICACY OF TRIGONELLA FOENUM GRAECUM SEED EXTRACT IN STREPTOZOTOCIN INDUCED DIABETES IN RATS. ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 9, page no.e441-e446, September-2021, Available :http://www.jetir.org/papers/JETIR2109562.pdf

"PATHOMORPHOLOGICAL EVALUATION OF ANTIDIABETIC EFFICACY OF TRIGONELLA FOENUM GRAECUM SEED EXTRACT IN STREPTOZOTOCIN INDUCED DIABETES IN RATS. ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 9, page no. ppe441-e446, September-2021, Available at : http://www.jetir.org/papers/JETIR2109562.pdf