• Dr. Sandhya Patre

N-arylhydroxamic acid shows drug likeliness therefore, the hydrogen bond donor (HBD), hydrogen bond acceptor (HBA) and solubility ratio (So/Sw) of three such molecules N-phenylbenzohydroxamic acid, were measured in water and co-solvent system by shake-flask method following the measurement of the concentration by UV spectroscopy. Solubility, partition phenomena and lipophilicity are the three important physico-chemical parameters to be screened at early stage of the drug development process. Solubility of solid compound in solvent is governed by interactions between molecules in the crystal lattice, intermolecular interactions in the solution and the entropy changes accompying fusion and dissolution. The salvation parameter gives comparable estimates to that of the group contribution method for estimating the lipophilicity of the molecules. The solubility and salvation parameter gives good estimate of the partition coefficient for the solutes used in the present study.

Hydroxamic acid, solubility and solvation parameters.

"Solvation Parameters and Solubility of N-Arylhydroxamic Acid", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 10, page no.a443-a447, October-2021, Available :http://www.jetir.org/papers/JETIR2110055.pdf

"Solvation Parameters and Solubility of N-Arylhydroxamic Acid", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 10, page no. ppa443-a447, October-2021, Available at : http://www.jetir.org/papers/JETIR2110055.pdf