UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 8 Issue 10
October-2021
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2110105


Registration ID:
313264

Page Number

b32-b42

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Title

FORMULATION AND EVALUATION OF MICROPARTICLES OF GLIBENCLAMIDE

Abstract

Sustained release drug delivery systems are more preferred than the conventional drug delivery systems due to its enhanced bioavailablity and patient compliance.Glibenclamide is a sulfonylurea used in the management of diabetes mellitus.The aim of this study was the Formulation and Physicochemical characterization of Glibenclamide by using polymers like chitosan and Arachis oil at different concentrations.The polymeric systems were prepared as microparticles through Ionic Gelation method, using pentasodium tripolyphosphate(TPP) as crosslinking agent.The polymeric systems obtained were characterized in terms of particle size and morphology,IR spectroscopy, entrapment efficiencyand drug loading, Swelling degree, the release of active substances from the chitosan matrix and the other micromeritic studies like Carr’s index, Hausner’s ratio, and angle of repose.It was observed from the invitro release studies, formulations F7and F8 showed sustained drug release for desired time of 12h and the drug release from microparticles follow non-Fickian diffusion mechanism.

Key Words

Glibenclamide, Chitosan, Ionic Gelation method, Tripolyphosphate, In-vitro diffusion studies.

Cite This Article

" FORMULATION AND EVALUATION OF MICROPARTICLES OF GLIBENCLAMIDE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 10, page no.b32-b42, October-2021, Available :http://www.jetir.org/papers/JETIR2110105.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

" FORMULATION AND EVALUATION OF MICROPARTICLES OF GLIBENCLAMIDE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 10, page no. ppb32-b42, October-2021, Available at : http://www.jetir.org/papers/JETIR2110105.pdf

Publication Details

Published Paper ID: JETIR2110105
Registration ID: 313264
Published In: Volume 8 | Issue 10 | Year October-2021
DOI (Digital Object Identifier):
Page No: b32-b42
Country: narasaraopeta, ANDHRA PRADESH, India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication


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