• Jisha S
• S.Usha

Njavara rice (Oryza sativa L. indica) is known to be a highly nutritious and medicinal variety of rice, indigenous to Kerala. Rice bran contains many bioactive ingredients showing antioxidant, antiproliferative, anti-inflammatory properties and found to be effective against hypercholesterolemia. In the present study the genotoxicity and antigenotoxicity of the water extract of Njavara rice was investigated. The mutagenicity and antimutagenicity of the extract were determined using a Salmonella mutation assay. Njavara rice extract was non mutagenic in TA100 strains in the absence of metabolic activation. The extract showed strong antimutagenic activity against sodium azide, a potent mutagen with an inhibition percentage of 64.5 to 87%. The inhibitory mechanism of this rice extract might be partly due to either induction of detoxifying enzymes or inhibition of metabolizing enzymes or the presence of compounds like polyphenols. Further studies must be undertaken to identify the compounds behind these properties.

Njavara rice, antigenotoxicity, Ames test, chemoprevention.

"ANTIGENOTOXIC PROPERTIES OF NJAVARA RICE ORYZA SATIVA L. INDICA AN INDIGENOUS MEDICINAL RICE VARIETY OF KERALA", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 10, page no.b445-b449, October-2021, Available :http://www.jetir.org/papers/JETIR2110147.pdf

"ANTIGENOTOXIC PROPERTIES OF NJAVARA RICE ORYZA SATIVA L. INDICA AN INDIGENOUS MEDICINAL RICE VARIETY OF KERALA", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 10, page no. ppb445-b449, October-2021, Available at : http://www.jetir.org/papers/JETIR2110147.pdf