• Dr.P.Lakshmaiah
• Uppuluri spandana
• R.Narasimha Naik

Abstract Terminalia chebula Retz (T. chebula) which is a member of the Combretaceae family is frequently used medicinal herb in Ayurvedic, Unani, and Siddha & Homeopathy system of medicine. Terminalia chebula is called the ‘King of Medicine’ in Tibet and is always listed at the top of the list in Ayurvedic Materia Medica due to its extraordinary power of healing. To evaluate the Terminalia chebula fruit extracts against neurodegenerative disorders in rodents. To screen the Terminalia chebula fruit extracts against haloperidol induced catatonia model in SD rats (Anti-parkinsonism/ catatonia activity), ethanol- induced cognitive impairment & diazepam induced amnesia (learning and memory activity in Alzheimer's disease).For anti-parkinsonism activity scoring of Catalepsy by using block method and motor activity by using actophotometer whereas learning and memory activity was performed to evaluate the effect of Terminalia chebula on Alzheimer’s disease by using the 8-arm radial maze (8-RAM), Morris water maze (MWM)& histopathological studies by comparing with the control group.

KEYWORDS: Terminalia chebula Retz, neurodegenerative disorders, anti-parkinsonism activity, learning and memory activity in Alzheimer’s disease & histopathological studies.

"PHARMACOLOGICAL SCREENING OF TERMINALIA CHEBULA FRUIT EXTRACTS AGAINST NEURO DEGENERATIVE DISORDERS IN RODENTS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 11, page no.c213-c227, November-2021, Available :http://www.jetir.org/papers/JETIR2111227.pdf

"PHARMACOLOGICAL SCREENING OF TERMINALIA CHEBULA FRUIT EXTRACTS AGAINST NEURO DEGENERATIVE DISORDERS IN RODENTS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 11, page no. ppc213-c227, November-2021, Available at : http://www.jetir.org/papers/JETIR2111227.pdf