• Shweta Chouksey
• Laxmi Gond

Abstract: A biodegradable film was prepared from psyllium seed husk, dimer acid (a dimer of ricinoleic acid derived from castor oil) and polyvinyl alcohol. Film was characterized by FTIR spectroscopy, X-ray diffraction analysis and scanning electron microscopy. Film exhibits optimal mechanical strength with UV protective effect and restricted entry of chemical contaminants. Film can be easily disposed by burying in soil. Films may be a potential eco-friendly food packaging material. Film was loaded with crystal violet and the release data were analysed using zero order, first-order, Higuchi, Hixson–Crowell and Korsmeyer–Peppas kinetic models. Release medium affected the mechanism of drug release. Release medium affected the mechanism of drug release. Release of CV from PDCV perfectly followed Higuchi drug release model. Fickian diffusion was observed at pH 4 and super case-II transport at pH 9. At pH 7, PBS and aqueous medium Fickian diffusion and swelling-induced polymer chain relaxation followed by gel surface erosion was inferred, which accounts for zero-order release. The film conformed to the attributes of a good film dressing.

Biodegradable film, crystal violet, release kinetics, psyllium seed husk, dimer acid.

"Biodegradable Film From Psyllium Seed Husk For Slow Drug Release: In Vitro Investigation", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 12, page no.b44-b48, December-2021, Available :http://www.jetir.org/papers/JETIR2112108.pdf

"Biodegradable Film From Psyllium Seed Husk For Slow Drug Release: In Vitro Investigation", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 12, page no. ppb44-b48, December-2021, Available at : http://www.jetir.org/papers/JETIR2112108.pdf