• MADHAVI DEVARAKONDA
• vijaya kumar.p
• Saileela ramanayam
• L.K Ravindranath

The present work to develop new anti-bacterial agents, design, synthesis, anti-microbial activities and molecular docking study of 2-(4-substituted) phenoxy-1,3,2-benzodioxaphosphole-2-oxide derivatives containing 1,2,3,4-tetrazol-benzoxozole system. Eight compounds (9a-h) having tetrazol-benzoxozole system were synthesized by chemical methods. The structures of these analogues (9a-h) have been established by 1H NMR, IR, Mass spectral data and elemental analysis. After conformation anti-microbial activity was evaluated by using disc diffusion method. Among eight analogues (9a-h) only three analogues (9d,9e,9f) exhibited significant anti-microbial activity. The synthesized analogues were docked into binding sites of sortase A and evaluated and few analogues shown better activity.

Polyphosphoric acid, substituted phenylphosphorodichloridate, benzoxazole, tetrazole., sortase A, molecular docking

"Design, synthesis, characterisation, molecular docking and anti-microbial evaluation of novel 2-(4-substituted) phenoxy-1,3,2-benzodioxaphosphole-2-oxide derivatives containing 1,2,3,4-tetrazol-benzoxozole system as anti-bacterial agents", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 12, page no.c131-c145, December-2021, Available :http://www.jetir.org/papers/JETIR2112218.pdf

"Design, synthesis, characterisation, molecular docking and anti-microbial evaluation of novel 2-(4-substituted) phenoxy-1,3,2-benzodioxaphosphole-2-oxide derivatives containing 1,2,3,4-tetrazol-benzoxozole system as anti-bacterial agents", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 12, page no. ppc131-c145, December-2021, Available at : http://www.jetir.org/papers/JETIR2112218.pdf