• Shikha Sharma
• Dr. Arun Kumar
• Sweta Rawal

The sustain release drug delivery system was developed to obtain prolonged pharmacological action by the continuous release of medicine after the drug administration along with minimum side effects. This can be an advanced approach towards the drugs with short half-life, elimination rate and are absorbed from the absorption window. The microspheres are termed as solid and curved molecules (1-1000 μm), with colloidal properties and a great proportion with respect to surface and volume. The microspheres are made up of wax, polymers (polyglycolic acid (PGA), polylactic acid (PLA) and natural products (starch, gum, protein, fat and wax etc). For the microspheres formulation, the polymer dissolving solvents are selected on the basis of drug-polymer solubility and stability, process safety and financial considerations. The interfacial properties of microspheres play an important role by indicating their activity. Verapamil hydrochloride (VRH) is a drug of choice for microsphere formulation process. It is categorized as calcium channel blocker with a half-life of about 2.8-7.4 hours and approximately 90% absorption rate. It is commonly used in cardiac arrhythmias and hypertension. The goal of this study is to review the formulation and evaluation techniques of Verapamil hydrochloride microspheres (VRHMs) which is meaningful in contrast of highlighted formulation techniques, drug selection parameters and advance novel research for SRDDs by an ionotropic gelation method using different polymers like Guar gum, Xanthan gum, HPMC (K100M) and Sodium alginate (SA) as a cross linking agent.

Verapamil hydrochloride, Sustain release, Microspheres, Ionotropic gelation, Natural polymers, Sodium Alginate

"A review on preparation and estimation techniques of sustain released Verapamil Hydrochloride microspheres", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 12, page no.c172-c179, December-2021, Available :http://www.jetir.org/papers/JETIR2112222.pdf

"A review on preparation and estimation techniques of sustain released Verapamil Hydrochloride microspheres", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 12, page no. ppc172-c179, December-2021, Available at : http://www.jetir.org/papers/JETIR2112222.pdf