• KISHORKUMAR K DHOLWANI
• RAJESH DODIYA

Matrix type poly herbal formulation (PHF) was carried out by freeze drying method, by employing maltodextrin (MD), sodium alginate (SA) and gelatine (GE) with their designated different combinations as encapsulating wall materials. Various bioactive components like total phenol contents (TPC), total flavonoids content (TFC), antioxidant activity (i.e. DPPH and ABTS+ [2,2’-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid] assays), moisture contents, water activity (aw), solubility, hygroscopicity, glass transition temperature (Tg), in vitro α-amylase and α-glycosidase inhibition and bioavailability ratios of the powders were investigated. Among all products, KD1 (5% SA and 5% MD) and KD4 (10% SA) have proven to be the best treatments with respect to the highest preservation of antioxidant components. These treatments also exhibited higher antioxidant potential by DPPH and an ABTS+ assays. Moreover, the aforesaid treatments also demonstrated lower moisture content, water activity (aw), hygroscopicity and glass transition temperature (Tg). All freeze dried samples showed irregular (asymmetrical) microcrystalline structures. KD1 and KD4 illustrated the highest in vitro anti-diabetic potential due to great potency for inhibiting α-amylase and α-glucosidase activities.

Matrix Poly herbal formulation, total phenolic content, total flavonoids content, Salacia prenoids, Coccinia indica, Annona squamosa

"Development and In-vitro Evaluation of Antidiabetic Potential of Matrix Type Polyherbal Formulation", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 12, page no.d365-d389, December-2021, Available :http://www.jetir.org/papers/JETIR2112346.pdf

"Development and In-vitro Evaluation of Antidiabetic Potential of Matrix Type Polyherbal Formulation", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 12, page no. ppd365-d389, December-2021, Available at : http://www.jetir.org/papers/JETIR2112346.pdf