• Saileela Ramayanam
• M.Murali krishna
• Madhavi Devarakonda
• Vijaya kumar polem
• L K Ravindranath

5-(5-(quinolin-4-yl)-1,3,4-oxadiazol-2-yl)-4- substituted phenoxy)benzo[d] [1,3,2] dioxaphosphol-2-oxide (7a-g) were synthesized by condensing 4-(5-(quinolin-4-yl)-1,3,4-oxadiazol-2-yl)benzene-1,2,-diols(5) with 4-substituted phenyl phosphorodichloridates(6a-g). The synthon (5) was synthesized by hydrolysis of 2-(3,4-dimethoxy phenyl)-5-(quinolin-4-yl)-1,3,4-oxadiazole (4). The intermediate (4) was synthesized by condensing quinoline-4-carbohydrazide(2) with 3,4-dimethoxy benzoic acid(3). Starting intermediate (2) was synthesized by condensation reaction between ethyl quinoline-4-carboxylate (1) and hydrazine hydrate, ethanol. The reagent and conditions were shown in a,b,c and d. The synthetic route was shown in scheme-I. The target molecule (7a-g) were characterized by IR,1H-NMR,13C-NMR,Mass and elemental analysis. The target molecules were subjected to biological evaluation and docking studies. The results observed in the present investigation were reported in the present research article.

Quinoline-4-carbohydrazide, 3,4-dimethoxy benzoic acid, 4-substituted phenyl phosphodichloridates, target molecule, Biological evaluation, molecular docking

"Synthesis, Characterization and Antimicrobial Evaluation and molecular docking studies of 5-(5-(quinolin-4-yl)-1,3,4-oxadiazol-2-yl)-4-substituted phenoxy)-benzo[d] [1,3,2] dioxaphosphol-2-oxide ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 12, page no.e151-e166, December-2021, Available :http://www.jetir.org/papers/JETIR2112419.pdf

"Synthesis, Characterization and Antimicrobial Evaluation and molecular docking studies of 5-(5-(quinolin-4-yl)-1,3,4-oxadiazol-2-yl)-4-substituted phenoxy)-benzo[d] [1,3,2] dioxaphosphol-2-oxide ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 12, page no. ppe151-e166, December-2021, Available at : http://www.jetir.org/papers/JETIR2112419.pdf