• Madhu
• Dr. Dinesh kaushik

Nanoparticles are of great scientific interest as they are effectively a bridge between bulk materials and atomic or molecular structures.(4) Presently, numerous of methods have been reported for the synthesis of nanoparticles. Size reduction of targeted formulation and designing its pathways for suitable drug delivery system is a more fundamental and successful approach that forms the basis of nanotechnology. Recent advancement in nanotechnology has proven that nanoparticles acquire a great potential as drug carriers. Size reduction methods and technologies yields different types of nanostructures that exhibit unique physicochemical and biological properties. MATERIALS: Curcumin (Loba chemie Pvt. Ltd., Mumbai), Methanol (Loba chemie Pvt. Ltd., Mumbai), Ethanol (Loba chemie Pvt. Ltd., Mumbai), Gelatin (Loba chemie Pvt. Ltd., Mumbai,) The main aim of the research work was to develop a nanoparticles. On characterization spherical nanoparticles with smooth surface were observed under transmission electron microscopy (TEM). Zeta potential of NPs provides satisfactory evidence about their little tendency towards aggregation when its negative charge confirms the presence of strong electric charges on the particle surfaces to hinder agglomeration. The X-ray diffraction pattern of the synthesized nanoparticles showed diffraction peaks at 2θ, which are compared with standard powder diffraction peaks. The experiments on particle size characterization confirmed that the synthesis of nanoparticles in the growth media was successful and had also provided us with estimates about the particle size and morphology. CONCLUSION: According to antibiotics screening results zone of inhibition formulation showed more activity for S. aureus and P Aerugonisa. NPs formulation of Curcumin alters the chemical structure of Curcumin and it becomes active against resistant bacteria.

Nanoparticles, Curcumin, Antibacterial activity

"DESIGN AND DEVELOPMENT OF CURCUMIN LOADED NANOPARTICLES FOR ANTIBACTERIAL ACTIVITY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 12, page no.f65-f81, December-2021, Available :http://www.jetir.org/papers/JETIR2112509.pdf

"DESIGN AND DEVELOPMENT OF CURCUMIN LOADED NANOPARTICLES FOR ANTIBACTERIAL ACTIVITY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 12, page no. ppf65-f81, December-2021, Available at : http://www.jetir.org/papers/JETIR2112509.pdf