• Saileela Ramayanam
• M.Murali krishna
• Madhavi Devarakonda
• Vijaya kumar polem
• L K Ravindranath

2-(2-oxido-2-phenoxy benzo[d][1,3,2]dioxaphosphol-5-yl)-3-(quinolin-6-yl)thiazolidin-4-one (7a-g) were synthesized by condensing 2-(3,4-dihydroxy phenyl)-3-(quinoline-6-yl) thiazolidin-4-one(5) with 4-substituted phenyl phosphorodichloridates(6a-g). The synthon (5) was synthesized by hydrolysis of 2-(3,4-dimethoxy phenyl)-3-(quinoline-6-yl)thiazolidin-4-one (4). The intermediate (4) was synthesized by condensing 1-(3,4-dimethoxy phenyl)-N-(quinoline-6-yl)methanimine (3) with mercaptoacetic acid in dioxane. Starting intermediate (3) was synthesized by condensation reaction between quinoline-6-amine (1) and 3,4-dimethoxy benzaldehyde (2). The reagent and conditions were shown in a,b,c and d. The synthetic route was shown in scheme-I. The target molecule (7a-g) were characterized by IR,1H-NMR,13C-NMR,Mass and elemental analysis. The target molecules were subjected to biological evaluation and docking studies. The results observed in the present investigation were reported in the present research article.

Quinolin-6-amine, 3,4-dimethoxy benzaldehyde, 4-substituted phenyl phosphodichloridates, Mercaptoacetic acid, Biological evaluation, molecular docking.

"Synthesis, Characterization, Antimicrobial Evaluation and molecular docking of (4-substituted phenoxy)benzo[d][1,3,2] dioxaphosphol-5-yl)-3-(quinoline-6-yl)thiazolidin-4-ones", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 1, page no.b103-b116, January-2022, Available :http://www.jetir.org/papers/JETIR2201115.pdf

"Synthesis, Characterization, Antimicrobial Evaluation and molecular docking of (4-substituted phenoxy)benzo[d][1,3,2] dioxaphosphol-5-yl)-3-(quinoline-6-yl)thiazolidin-4-ones", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 1, page no. ppb103-b116, January-2022, Available at : http://www.jetir.org/papers/JETIR2201115.pdf