• Bal Krishan

The present work describes Thermal and XRD studies of cobalt complex of N-(hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbamoyl)-4-methylbenzenesulfonamide or Gliglazide, an oral antidiabetic drug. Complex of cobalt was synthesized and characterized by TGA and X-ray diffraction Metal ligand ratio was determined by Monovariation method indicate the formation of non-ionic complex and L2M (2:1) type and further confirmed by Job’s method of continuous variation. Analytical data agrees with the molecular formula of complex viz.(C15H20N3O3S)2Co2H2O. Structure (Scheme-2) have been discussed and suggested upon Elemental analysis, Electronic spectra. Powder X-ray diffraction data was performed on metal complex. XRD pattern indicate crystalline nature of complex. XRD data have been used to calculate particle size, porosity, volume of unit cell and density of synthesized complex. The freeman-Carroll and Sharp-Wentworth methods was used to calculate activation energy and thermal stability. Thermodynamic parameters such as free energy change (ΔG), entropy change (-ΔS), order of reaction (n) is also determined on the basis of TGA/DTA curves by using data of the Freeman-Carroll method.

Gliclazide, complex, TGA and X-Ray diffraction

"THERMAL AND XRD STUDY OF METAL COMPLEX OF N-(HEXAHYDROCYCLOPENTA[C]PYRROL-2(1H)-LCARBAMOYL) - 4-METHYLBENZENESULFONAMIDE ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 1, page no.d524-d534, January-2022, Available :http://www.jetir.org/papers/JETIR2201366.pdf

"THERMAL AND XRD STUDY OF METAL COMPLEX OF N-(HEXAHYDROCYCLOPENTA[C]PYRROL-2(1H)-LCARBAMOYL) - 4-METHYLBENZENESULFONAMIDE ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 1, page no. ppd524-d534, January-2022, Available at : http://www.jetir.org/papers/JETIR2201366.pdf