• Hema Chandrakant shende

Drug discovery and development is very difficult challenge for the pharmaceutical industries. It requires lengthy time period to discover and develop new drug. In this review article we are discussing about whole procedure involved in drug discovery that is paradigm for new drug discovery, innovative deficit, mainly focuses on actual process that is how target identification as well as validation is done, lead compounds identification and optimization this both processes are also comes under this lengthy and costly drug discovery procedure. Preclinical and clinical evaluation discovered drug that is newly developed drug is primarily done on some animal by following in vitro studies and then after completion its in vitro and animal studies it is almost ready for the further trails on human beings. Clinical trials involves some systematic phases, which evaluate the developed drug on the basis of safety and efficacy. If drug passed all the phases of clinical trail it ready to approved by food and drug administration (FDA) and then it is ready for deliver to the market.

Drug discover, Food and Drug Administration, Target discovery, Target validation, Lead optimization, Pre-clinical studies, clinical trail.

"Drug Discovery And Clinical Evaluation Of New Drug", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 2, page no.b314-b326, February-2022, Available :http://www.jetir.org/papers/JETIR2202135.pdf

"Drug Discovery And Clinical Evaluation Of New Drug", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 2, page no. ppb314-b326, February-2022, Available at : http://www.jetir.org/papers/JETIR2202135.pdf