• Rohitkumar R Jajoo
• Amol j Giri
• P R Tathe
• N I Kochar

Epilepsy is a chronic neurological disorder. The plant materials Mucuna birdwoodiana Tutcher, This species is accepted and its native range is S. China, Mucuna andreana Micheli and Mucuna holtonii. The extract showed no toxicity and significantly prolonged the onset and reduced the duration of the seizures induced by MES. Phenytoin (25 mg/kg, i.p.) completely inhibited the seizures in this model. Similarly, in the seizures induced by PTZ and INH, the extract also prolonged the onset and reduced the duration of the seizures though not in a dose‑ dependent manner. Diazepam also inhibits the PTZ and INH‑ induced seizures. The plant extract however showed a significant anticonvulsant activity at 400 mg/kg in comparison with diazepam. The extract also attenuates the chemical (PTZ) induce oxidative stress in the brain. Moreover, the extract (400 mg/kg) also significantly decreases the GABA‑ transaminase enzyme activity in PTZ model. The PHF was also found to be capable in reversing the INH‑ induced decline in GABA level and increase in glutamate level in the brain.

neurological disorder, Anticonvulsant activity, epilepsy, maximal electric shock, Polyherbal formulation.

"Evaluation of anticonvulsant activity of polyherbal extracts of Mucuna birdwoodiana Tutcher, Mucuna andreana Micheli and Mucuna holtonii in albino rats.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 2, page no.b520-b525, February-2022, Available :http://www.jetir.org/papers/JETIR2202161.pdf

"Evaluation of anticonvulsant activity of polyherbal extracts of Mucuna birdwoodiana Tutcher, Mucuna andreana Micheli and Mucuna holtonii in albino rats.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 2, page no. ppb520-b525, February-2022, Available at : http://www.jetir.org/papers/JETIR2202161.pdf