• SP Malarkannan
• P Dharumarajan
• Markandeyan Devaprasad
• MK Hariyohesh

Aims and objectives The important aspect of medicine to utilize as an antiviral drug is not only to cure the viral infection but also to increase the immunity of the patients is the prime importance to control the infection. Methodology In this study, the immunomodulatory activity of purified Siddha herbal formulation MV kashayam at the concentration of 5ml and 10ml/kg b.w. was planned on cyclophosphamide (CYP) treated immuno-suppressed albino Wistar rats and compared with the standard immune-activating drug levamisole. Results and conclusion The result showed that the purified Siddha formulation MV kashayam treatment provides a significant increase in a protective effect on hematopoietic cells like (Haemoglobin) Hb, RBC, WBC, platelet cells as against CYP induced immune-toxicity and in case of delayed-type hypersensitivity reaction (DTH) showed 30% and 43% higher volume in the thickness of footpad. The phagocytic index level increased significantly and provides protection against oxidative stress triggered by CYP and recover the damage. The organ weight index of the spleen, liver, kidney and heart showed that they have recovered to normal condition in a short period. CYP treatment significantly elevated the levels of macromolecule damage (MDA and PCO) and decrease the levels of enzymatic (SOD and CAT), non-enzymatic (GSH) antioxidant status in the liver. At the same time, treatment with MV kashayam reverse the effect of CYP induced damage via increasing CAT, SOD and GSH levels and thus protecting macromolecular damage and decreasing MDA and PCO level. The morphological analysis also supports the above study and shows the ability of Siddha formulation MV kashayam to repair the damage caused by CYP induced oxidative stress.

Siddha herbal formulation - MV kashayam- Immunomodulatory effect - immunosuppressed rats

"IMMUNOMODULATORY ACTIVITY OF SIDDHA HERBAL FORMULATION MV KASHAYAM ON CYCLOPHOSPHAMIDE TREATED IMMUNOSUPPRESSED RATS ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 2, page no.c133-c147, February-2022, Available :http://www.jetir.org/papers/JETIR2202237.pdf

"IMMUNOMODULATORY ACTIVITY OF SIDDHA HERBAL FORMULATION MV KASHAYAM ON CYCLOPHOSPHAMIDE TREATED IMMUNOSUPPRESSED RATS ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 2, page no. ppc133-c147, February-2022, Available at : http://www.jetir.org/papers/JETIR2202237.pdf