• Bapurao S. Patange
• Dr. V. N. Deshmukh

Gastro-retentive drug delivery System is a Novel Drug Delivery which is mainly Comprised of Floating, Mucoadhesive, Swellable and High Density system. Floating Drug delivery system meants for gastic retention, float on the surface of the gastric fluids, due to their low density and produce prolonged effect by showing release, while being buoyant on gatric fluid surface.In-situ gels are the solutions or suspensions that undergo gelation after reaching the particular site due to contact with body fluids or physicochemical changes. Conventional oral dosage forms having low bioavailability due to rapid gastric transition from stomach and requires more dosing frequencies, the floating oral in situ gel have a ability to overcome these problems. Floating oral In-Situ gelling System having controlled released and site specific drug delivery hence it has a great interest to researchers in pharmaceuticals to improve the therapeutic advantages. In these review we discuss the Gastro-retentive drug delivery system specially Floating oral in-Situ gelling system with Natural and Synthetic polymers, Approaches of formulation and its brief Evaluation Parameters that having great advantages in Pharmaceutical formulations.

Floating drug delivery, In-situ gel, buoyant, swelling polymers, cross-linking, gelation, FTIR etc.

"Floating oral In-Situ Gel:A Review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 2, page no.c274-c287, February-2022, Available :http://www.jetir.org/papers/JETIR2202254.pdf

"Floating oral In-Situ Gel:A Review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 2, page no. ppc274-c287, February-2022, Available at : http://www.jetir.org/papers/JETIR2202254.pdf