• Sonali Baban Pawar
• Dr. Vijaykumar S. Wakale
• Sachin Shankar Borude
• Sandesh Sachhidanand Bole
• Akshada Dilip Suryawanshi

The transdermal drug delivery system now becomes a promising and efficient route of drug delivery system. It has a possible benefit of avoiding first pass metabolism, improved patient compliance, decrease side effect and improved bioavailability.The purpose of this research was to develop a matrix type transdermal system containing drug Clopidogrel bisulfate with polymer ratio of HPMC E5 and ERS-100 by solvent evaporation technique by using polyethylene glycol 400 as a plasticizer and varying concentration of penetration enhancers (Tea tree oil, Sweet basil oil, Eucalyptus oil, Dimethyl sulphoxide and clove oil). The prepared formulations were characterized by FT-IR and DSC to estimate the incompatibility. The physical appearance, thickness, percent moisture absorption, percent moisture loss, water vapour transmission rate, folding endurance, and medication content of the prepared transdermal patches were all assessed. The in-vitro diffusion studies of formulations were completed by using Franz diffusion cell, from the above study it was found that batch SN6 (A1) and SP5 (A2) showed highest cumulative percent drug release. The microscopic research done out by using scanning electron microscope.

TDDS, Clopidogrel bisulfate, Polyethylene glycol, in-vitro diffusion study.

"DEVELOPMENT OF CLOPIDOGREL BISULFATE TRANSDERMAL PATCHES AND ESTIMATION OF SIGNIFICANT EFFECT OF VARIABLES BY USING FACTORIAL DESIGN.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 3, page no.a520-a558, March-2022, Available :http://www.jetir.org/papers/JETIR2203063.pdf

"DEVELOPMENT OF CLOPIDOGREL BISULFATE TRANSDERMAL PATCHES AND ESTIMATION OF SIGNIFICANT EFFECT OF VARIABLES BY USING FACTORIAL DESIGN.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 3, page no. ppa520-a558, March-2022, Available at : http://www.jetir.org/papers/JETIR2203063.pdf