• Dr. Devaraju
• Dr.Santhosha S. Poojary
• Dr. Ranjini. P
• Dr. Rekha N. D
• Dr,N.Nanjundaswamy

Abstract: The current COVID-19 emergency warrants the urgent development of potential strategies to protect people at high risk of infection Series of novel substituted phenyl derivatives of acyclovir were efficiently synthesized in high yields and their biological activity was studied. 2-amino-9-((2-hydroxy ethoxy) methyl)-1H-purin-6(9H)-one (acyclovir) (1) was made to react with various substituted phenyl moiety (2a-j) in presence of dicyclohexyl carbodiimide and N,N-dimethylamino pyridine using N,N-dimethyl formamide to obtain the acyclovir derivatives 3a–j. The structures of the synthesized compounds (3a–j) were confirmed by IR, 1H NMR, 13C NMR and mass spectral data and elemental analysis. The newly synthesized compounds were screened for their antimicrobial, antioxidant activity against acyclovir and antioxidant activity was evaluated by the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) scavenging methods. The title compounds exhibited potent antimicrobial and good antioxidant activities.

acyclovir, dicyclohexyl carbodiimide, N,N-dimethylamino pyridine, N,N-dimethyl formamide antimicrobial, antioxidant.

"Synthesis and biological screening of novel 2-((2-amino-6-oxo-1H-purin-9 (6H)-yl) methoxy) ethyl substituted benzoate .", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 3, page no.a833-a843, March-2022, Available :http://www.jetir.org/papers/JETIR2203100.pdf

"Synthesis and biological screening of novel 2-((2-amino-6-oxo-1H-purin-9 (6H)-yl) methoxy) ethyl substituted benzoate .", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 3, page no. ppa833-a843, March-2022, Available at : http://www.jetir.org/papers/JETIR2203100.pdf