• Richa Shahwal
• Arpita Srivastav
• Dr. Arunima Sur

Cypermethrin is one of the most common toxic substances in freshwater systems used to control the pests of internal and external systems. In the present study, the toxicity of the development of Zebrafish embryos was carefully evaluated and investigated the effects of CYP exposure on apoptosis in zebrafish. 4-h post-fertilization (HPF) zebrafish embryos have been exposed to different concentrations of cypermethrin for up to 96 hours. Various morphological abnormalities such as curvature of the body, enema were observed at very high altitudes. The activities of Antioxidative enzymes, namely, superoxide dismutase and catalase of zebrafish larvae are performed in a concentrated manner. In addition, the toxic effects of cypermethrin investigated in fish with acridine orange (AO) staining, the result showed apoptotic cells mainly in the areas of the head, nervous system, body, heart, and tail. The results show that Cypermethrin induces oxidative stress and exhibits apoptosis. In this study, the developmental toxicity of cypermethrin research using zebrafish embryos helped to understand the various mechanisms of exposure to cypermethrin and suggested that Zebrafish serve as an appropriate model for the testing of toxic substances.

Cypermethrin (CYP) Zebrafish Acridine orange Antioxidative biomarkers Acetylcholine esterase developmental toxicity

"To study the developmental and enzymatic effects of Cypermethrin on Zebrafish", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 3, page no.b16-b29, March-2022, Available :http://www.jetir.org/papers/JETIR2203102.pdf

"To study the developmental and enzymatic effects of Cypermethrin on Zebrafish", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 3, page no. ppb16-b29, March-2022, Available at : http://www.jetir.org/papers/JETIR2203102.pdf